MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1-mediated...
MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1-mediated oxidative phosphorylation
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Author / Creator
Li, Yujing , Cai, Minglong , Qin, Yi , Dai, Xiaojuan , Liang, Liyuan , Li, Zhenyu , Wen, Xi , Jin, Huizhi , Yang, Chao and Chen, Zhu
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by disrupted bone homeostasis. This study investigated the effect and underlying mechanisms of one-carbon metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) on osteoclast differentiation and bone loss in RA.
The expression of MTHFD2 was examined in CD14 + m...
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Full title
MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1-mediated oxidative phosphorylation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9b22cb959fc244fc8c7e06b947a7f617
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9b22cb959fc244fc8c7e06b947a7f617
Other Identifiers
ISSN
1741-7015
E-ISSN
1741-7015
DOI
10.1186/s12916-025-03945-y
