Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-depen...
Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Diverse cellular processes depend on the lysosomal protease system but how cells regulate lysosomal proteolytic capacity is only partly understood. We show here that cells can respond to protease/substrate imbalance in this compartment by de novo expression of multiple lysosomal hydrolases. This response, exemplified here either by loss of asparagi...
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Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
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TN_cdi_doaj_primary_oai_doaj_org_article_9b365abacb3a4762883c30443e39abf9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9b365abacb3a4762883c30443e39abf9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07741-6
