Exploiting a novel conformational switch to control innate immunity mediated by complement protein C...
Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Complement C3a is an important protein in innate and adaptive immunity, but its specific roles in vivo remain uncertain because C3a degrades rapidly to form the C3a-desArg protein, which does not bind to the C3a receptor and is indistinguishable from C3a using antibodies. Here we develop the most potent, stable and highly selective small molecule m...
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Full title
Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a
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TN_cdi_doaj_primary_oai_doaj_org_article_9b55fdd2b33140c08bc5b8dacdba336c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9b55fdd2b33140c08bc5b8dacdba336c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00414-w
