CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
About this item
Full title
Author / Creator
Sun, Jichao , Carlson-Stevermer, Jared , Das, Utpal , Shen, Minjie , Delenclos, Marion , Snead, Amanda M. , Koo, So Yeon , Wang, Lina , Qiao, Dianhua , Loi, Jonathan , Petersen, Andrew J. , Stockton, Michael , Bhattacharyya, Anita , Jones, Mathew V. , Zhao, Xinyu , McLean, Pamela J. , Sproul, Andrew A. , Saha, Krishanu and Roy, Subhojit
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
CRISPR/Cas9 guided gene-editing is a potential therapeutic tool, however application to neurodegenerative disease models has been limited. Moreover, conventional mutation correction by gene-editing would only be relevant for the small fraction of neurodegenerative cases that are inherited. Here we introduce a CRISPR/Cas9-based strategy in cell and...
Alternative Titles
Full title
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
Authors, Artists and Contributors
Author / Creator
Carlson-Stevermer, Jared
Das, Utpal
Shen, Minjie
Delenclos, Marion
Snead, Amanda M.
Koo, So Yeon
Wang, Lina
Qiao, Dianhua
Loi, Jonathan
Petersen, Andrew J.
Stockton, Michael
Bhattacharyya, Anita
Jones, Mathew V.
Zhao, Xinyu
McLean, Pamela J.
Sproul, Andrew A.
Saha, Krishanu
Roy, Subhojit
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9b7514e64c5f429f8af27f9559663d3c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9b7514e64c5f429f8af27f9559663d3c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07971-8
