Structure optimization and molecular dynamics studies of new tumor-selective s -triazines targeting...
Structure optimization and molecular dynamics studies of new tumor-selective s -triazines targeting DNA and MMP-10/13 for halting colorectal and secondary liver cancers
About this item
Full title
Author / Creator
Publisher
England: Taylor & Francis Ltd
Journal title
Language
English
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Publication information
Publisher
England: Taylor & Francis Ltd
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Scope and Contents
Contents
A series of triazole-tethered triazines bearing pharmacophoric features of DNA-targeting agents and non-hydroxamate MMPs inhibitors were synthesized and screened against HCT-116, Caco-2 cells, and normal colonocytes by MTT assay.
and
surpassed doxorubicin against HCT-116 cells regarding potency (IC
= 0.87 and 1.41 nM) and safety (SI = 181....
Alternative Titles
Full title
Structure optimization and molecular dynamics studies of new tumor-selective s -triazines targeting DNA and MMP-10/13 for halting colorectal and secondary liver cancers
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9ba7052bfe054249a160cf6cfa89a7b8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9ba7052bfe054249a160cf6cfa89a7b8
Other Identifiers
ISSN
1475-6366,1475-6374
E-ISSN
1475-6374
DOI
10.1080/14756366.2024.2423174
