Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the...
Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex
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Full title
Author / Creator
Sun, Yilun , Baechler, Simone A. , Zhang, Xiaohu , Kumar, Suresh , Factor, Valentina M. , Arakawa, Yasuhiro , Chau, Cindy H. , Okamoto, Kanako , Parikh, Anup , Walker, Bob , Su, Yijun P. , Chen, Jiji , Ting, Tabitha , Huang, Shar-yin N. , Beck, Erin , Itkin, Zina , McKnight, Crystal , Xie, Changqing , Roper, Nitin , Nijhawan, Deepak , Figg, William Douglas , Meltzer, Paul S. , Yang, James C. , Thomas, Craig J. and Pommier, Yves
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human CRC cells. Combination of the TOP1 inhibitor irinotecan or its bioactive metabolite SN38 with the NEDD8-activating enzym...
Alternative Titles
Full title
Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex
Authors, Artists and Contributors
Author / Creator
Baechler, Simone A.
Zhang, Xiaohu
Kumar, Suresh
Factor, Valentina M.
Arakawa, Yasuhiro
Chau, Cindy H.
Okamoto, Kanako
Parikh, Anup
Walker, Bob
Su, Yijun P.
Chen, Jiji
Ting, Tabitha
Huang, Shar-yin N.
Beck, Erin
Itkin, Zina
McKnight, Crystal
Xie, Changqing
Roper, Nitin
Nijhawan, Deepak
Figg, William Douglas
Meltzer, Paul S.
Yang, James C.
Thomas, Craig J.
Pommier, Yves
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9bbad19d5fd14d8c895c04b8d779aa1f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9bbad19d5fd14d8c895c04b8d779aa1f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39374-9
