GWAS of epigenetic aging rates in blood reveals a critical role for TERT
GWAS of epigenetic aging rates in blood reveals a critical role for TERT
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Author / Creator
Lu, Ake T. , Xue, Luting , Salfati, Elias L. , Chen, Brian H. , Ferrucci, Luigi , Levy, Daniel , Joehanes, Roby , Murabito, Joanne M. , Kiel, Douglas P. , Tsai, Pei-Chien , Yet, Idil , Bell, Jordana T. , Mangino, Massimo , Tanaka, Toshiko , McRae, Allan F. , Marioni, Riccardo E. , Visscher, Peter M. , Wray, Naomi R. , Deary, Ian J. , Levine, Morgan E. , Quach, Austin , Assimes, Themistocles , Tsao, Philip S. , Absher, Devin , Stewart, James D. , Li, Yun , Reiner, Alex P. , Hou, Lifang , Baccarelli, Andrea A. , Whitsel, Eric A. , Aviv, Abraham , Cardona, Alexia , Day, Felix R. , Wareham, Nicholas J. , Perry, John R. B. , Ong, Ken K. , Raj, Kenneth , Lunetta, Kathryn L. and Horvath, Steve
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated wi...
Alternative Titles
Full title
GWAS of epigenetic aging rates in blood reveals a critical role for TERT
Authors, Artists and Contributors
Author / Creator
Xue, Luting
Salfati, Elias L.
Chen, Brian H.
Ferrucci, Luigi
Levy, Daniel
Joehanes, Roby
Murabito, Joanne M.
Kiel, Douglas P.
Tsai, Pei-Chien
Yet, Idil
Bell, Jordana T.
Mangino, Massimo
Tanaka, Toshiko
McRae, Allan F.
Marioni, Riccardo E.
Visscher, Peter M.
Wray, Naomi R.
Deary, Ian J.
Levine, Morgan E.
Quach, Austin
Assimes, Themistocles
Tsao, Philip S.
Absher, Devin
Stewart, James D.
Li, Yun
Reiner, Alex P.
Hou, Lifang
Baccarelli, Andrea A.
Whitsel, Eric A.
Aviv, Abraham
Cardona, Alexia
Day, Felix R.
Wareham, Nicholas J.
Perry, John R. B.
Ong, Ken K.
Raj, Kenneth
Lunetta, Kathryn L.
Horvath, Steve
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9c04cc5045d14339bb52c91c1cd6b779
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9c04cc5045d14339bb52c91c1cd6b779
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02697-5
