HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythrop...
HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Iron and heme play central roles in the production of red blood cells, but the underlying mechanisms remain incompletely understood. Heme-regulated eIF2α kinase (HRI) controls translation by phosphorylating eIF2α. Here, we investigate the global impact of iron, heme, and HRI on protein translation in vivo in murine primary erythroblasts using ribos...
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Full title
HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis
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TN_cdi_doaj_primary_oai_doaj_org_article_9c7a78b9c73a4cf8925af57b0da38a26
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9c7a78b9c73a4cf8925af57b0da38a26
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.46976
