TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Poor survival and lack of treatment response in glioblastoma (GBM) is attributed to the persistence of glioma stem cells (GSCs). To identify novel therapeutic approaches, we performed CRISPR/Cas9 knockout screens and discovered TGFβ activated kinase (TAK1) as a selective survival factor in a significant fraction of GSCs. Loss of TAK1 kinase activit...
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Full title
TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
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TN_cdi_doaj_primary_oai_doaj_org_article_9c882069fd714df8a02c424b20d4f84c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9c882069fd714df8a02c424b20d4f84c
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-06654-1
