A Natural Compound Containing a Disaccharide Structure of Glucose and Rhamnose Identified as Potenti...
A Natural Compound Containing a Disaccharide Structure of Glucose and Rhamnose Identified as Potential N-Glycanase 1 (NGLY1) Inhibitors
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Author / Creator
Liu, Ruijie , Gu, Jingjing , Ye, Yilin , Zhang, Yuxin , Zhang, Shaoxing , Lin, Qiange , Yuan, Shuying , Chen, Yanwen , Lu, Xinrong , Tong, Yongliang , Lv, Shaoxian , Chen, Li and Sun, Guiqin
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Switzerland: MDPI AG
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Scope and Contents
Contents
N-glycanase 1 (NGLY1) is an essential enzyme involved in the deglycosylation of misfolded glycoproteins through the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which could hydrolyze N-glycan from N-glycoprotein or N-glycopeptide in the cytosol. Recent studies indicated that NGLY1 inhibition is a potential novel drug target for...
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Full title
A Natural Compound Containing a Disaccharide Structure of Glucose and Rhamnose Identified as Potential N-Glycanase 1 (NGLY1) Inhibitors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9c903130e3ae49209d0ae66005cb71bc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9c903130e3ae49209d0ae66005cb71bc
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules28237758
