mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerati...
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
About this item
Full title
Author / Creator
Palmieri, Michela , Pal, Rituraj , Nelvagal, Hemanth R. , Lotfi, Parisa , Stinnett, Gary R. , Seymour, Michelle L. , Chaudhury, Arindam , Bajaj, Lakshya , Bondar, Vitaliy V. , Bremner, Laura , Saleem, Usama , Tse, Dennis Y. , Sanagasetti, Deepthi , Wu, Samuel M. , Neilson, Joel R. , Pereira, Fred A. , Pautler, Robia G. , Rodney, George G. , Cooper, Jonathan D. and Sardiello, Marco
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Neurodegenerative diseases characterized by aberrant accumulation of undigested cellular components represent unmet medical conditions for which the identification of actionable targets is urgently needed. Here we identify a pharmacologically actionable pathway that controls cellular clearance via Akt modulation of transcription factor EB (TFEB), a...
Alternative Titles
Full title
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
Authors, Artists and Contributors
Author / Creator
Pal, Rituraj
Nelvagal, Hemanth R.
Lotfi, Parisa
Stinnett, Gary R.
Seymour, Michelle L.
Chaudhury, Arindam
Bajaj, Lakshya
Bondar, Vitaliy V.
Bremner, Laura
Saleem, Usama
Tse, Dennis Y.
Sanagasetti, Deepthi
Wu, Samuel M.
Neilson, Joel R.
Pereira, Fred A.
Pautler, Robia G.
Rodney, George G.
Cooper, Jonathan D.
Sardiello, Marco
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9d01b8cdb7714197a5184f986c9a6f8a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9d01b8cdb7714197a5184f986c9a6f8a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14338
