Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
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Author / Creator
Vergari, Elisa , Knudsen, Jakob G. , Ramracheya, Reshma , Salehi, Albert , Zhang, Quan , Adam, Julie , Asterholm, Ingrid Wernstedt , Benrick, Anna , Briant, Linford J. B. , Chibalina, Margarita V. , Gribble, Fiona M. , Hamilton, Alexander , Hastoy, Benoit , Reimann, Frank , Rorsman, Nils J. G. , Spiliotis, Ioannis I. , Tarasov, Andrei , Wu, Yanling , Ashcroft, Frances M. , Rorsman, Patrik , Strategiska forskningsområden (SFO) , Profilområden och andra starka forskningsmiljöer , Lund University , EXODIAB: Excellence of Diabetes Research in Sweden , Profile areas and other strong research environments , Strategic research areas (SRA) and Lunds universitet
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory mechanism is impaired in diabetes. Here we show in mice th...
Alternative Titles
Full title
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
Authors, Artists and Contributors
Author / Creator
Knudsen, Jakob G.
Ramracheya, Reshma
Salehi, Albert
Zhang, Quan
Adam, Julie
Asterholm, Ingrid Wernstedt
Benrick, Anna
Briant, Linford J. B.
Chibalina, Margarita V.
Gribble, Fiona M.
Hamilton, Alexander
Hastoy, Benoit
Reimann, Frank
Rorsman, Nils J. G.
Spiliotis, Ioannis I.
Tarasov, Andrei
Wu, Yanling
Ashcroft, Frances M.
Rorsman, Patrik
Strategiska forskningsområden (SFO)
Profilområden och andra starka forskningsmiljöer
Lund University
EXODIAB: Excellence of Diabetes Research in Sweden
Profile areas and other strong research environments
Strategic research areas (SRA)
Lunds universitet
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9d4aeee6ff1d49cdae2f6687f5fe8637
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9d4aeee6ff1d49cdae2f6687f5fe8637
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-08193-8
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