mTOR pathway in human cardiac hypertrophy caused by LEOPARD syndrome: a different role compared with...
mTOR pathway in human cardiac hypertrophy caused by LEOPARD syndrome: a different role compared with animal models?
About this item
Full title
Author / Creator
Cui, Hao , Song, Lei , Zhu, Changsheng , Zhang, Ce , Tang, Bing , Wang, Shengwei , Wu, Guixin , Zou, Yubao , Huang, Xiaohong , Hui, Rutai , Wang, Shuiyun and Wang, Jizheng
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Animal studies suggested that blocking the activation of the mammalian target of rapamycin (mTOR) pathway might be effective to treat cardiac hypertrophy in LEOPARD syndrome (LS) caused by PTPN11 mutations.
In the present study, mTOR pathway activity was examined in human myocardial samples from two patients with LS, four patients with hypertrop...
Alternative Titles
Full title
mTOR pathway in human cardiac hypertrophy caused by LEOPARD syndrome: a different role compared with animal models?
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9ddeb846ac5a4947bebe02540fa476c5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9ddeb846ac5a4947bebe02540fa476c5
Other Identifiers
ISSN
1750-1172
E-ISSN
1750-1172
DOI
10.1186/s13023-019-1204-4
