Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocyt...
Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes
About this item
Full title
Author / Creator
Moore, Timothy M. , Cheng, Lijing , Wolf, Dane M. , Ngo, Jennifer , Segawa, Mayuko , Zhu, Xiaopeng , Strumwasser, Alexander R. , Cao, Yang , Clifford, Bethan L. , Ma, Alice , Scumpia, Philip , Shirihai, Orian S. , Vallim, Thomas Q. de Aguiar , Laakso, Markku , Lusis, Aldons J. , Hevener, Andrea L. and Zhou, Zhenqi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control. However, the mechanisms by which Parkin connects mitochondrial homeostasis with cellular metabolism in adipose tissue remain unclear. Here, we demonstrate that
Park2
gene (encodes Parkin) deletion specifically from adipose tissue protects mice against hi...
Alternative Titles
Full title
Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9e68195a11cc43e7b96aa4f54f9e6c1a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9e68195a11cc43e7b96aa4f54f9e6c1a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34468-2
