The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interfe...
The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
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Author / Creator
Bhaskaran, Vivek , Nowicki, Michal O. , Idriss, Mahmoud , Jimenez, Miguel A. , Lugli, Gianmarco , Hayes, Josie L. , Mahmoud, Ahmad Bakur , Zane, Rachel E. , Passaro, Carmela , Ligon, Keith L. , Haas-Kogan, Daphne , Bronisz, Agnieszka , Godlewski, Jakub , Lawler, Sean E. , Chiocca, E. Antonio and Peruzzi, Pierpaolo
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
MicroRNA deregulation is a consistent feature of glioblastoma, yet the biological effect of each single gene is generally modest, and therapeutically negligible. Here we describe a module of microRNAs, constituted by miR-124, miR-128 and miR-137, which are co-expressed during neuronal differentiation and simultaneously lost in gliomagenesis. Each o...
Alternative Titles
Full title
The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
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TN_cdi_doaj_primary_oai_doaj_org_article_9eb6fe5b852d43329fafc6511460a696
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9eb6fe5b852d43329fafc6511460a696
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08390-z
