PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models
PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models
About this item
Full title
Author / Creator
Baldrighi, Marta , Doreth, Christian , Li, Yang , Zhao, Xiaohui , Warner, Emily , Chenoweth, Hannah , Kishore, Kamal , Umrania, Yagnesh , Minde, David-Paul , Thome, Sarah , Yu, Xian , Lu, Yuning , Knapton, Alice , Harrison, James , Clarke, Murray , Latz, Eicke , de Cárcer, Guillermo , Malumbres, Marcos , Ryffel, Bernhard , Bryant, Clare , Liu, Jinping , Lilley, Kathryn S. , Mallat, Ziad and Li, Xuan
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Unabated activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome is linked with the pathogenesis of various inflammatory disorders. Polo-like kinase 1 (PLK1) has been widely studied for its role in mitosis. Here, using both pharmacological and genetic approaches, we demonstrate that PLK1 promoted NLRP3 inflammasome activation at...
Alternative Titles
Full title
PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models
Authors, Artists and Contributors
Author / Creator
Doreth, Christian
Li, Yang
Zhao, Xiaohui
Warner, Emily
Chenoweth, Hannah
Kishore, Kamal
Umrania, Yagnesh
Minde, David-Paul
Thome, Sarah
Yu, Xian
Lu, Yuning
Knapton, Alice
Harrison, James
Clarke, Murray
Latz, Eicke
de Cárcer, Guillermo
Malumbres, Marcos
Ryffel, Bernhard
Bryant, Clare
Liu, Jinping
Lilley, Kathryn S.
Mallat, Ziad
Li, Xuan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9ec59b6ac22e465f89c2f85931f35cac
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9ec59b6ac22e465f89c2f85931f35cac
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI162129
