Immunotherapeutic effects of intratumoral nanoplexed poly I:C
Immunotherapeutic effects of intratumoral nanoplexed poly I:C
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Full title
Author / Creator
Aznar, M. Angela , Planelles, Lourdes , Perez-Olivares, Mercedes , Molina, Carmen , Garasa, Saray , Etxeberría, Iñaki , Perez, Guiomar , Rodriguez, Inmaculada , Bolaños, Elixabet , Lopez-Casas, Pedro , Rodriguez-Ruiz, Maria E. , Perez-Gracia, Jose L. , Marquez-Rodas, Ivan , Teijeira, Alvaro , Quintero, Marisol and Melero, Ignacio
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I. BO-112 is a nanoplexed formulation of Poly I:C complexed with polyethylenimine that causes tumor cell apoptosis showing immunogenic cell death features and which upon intratumoral release results in more prominent tumor infiltration by T lymphocyt...
Alternative Titles
Full title
Immunotherapeutic effects of intratumoral nanoplexed poly I:C
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9eeebb0ed0f84c02b0ffa9b91f0acb00
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9eeebb0ed0f84c02b0ffa9b91f0acb00
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1186/s40425-019-0568-2
