An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in...
An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development
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Publisher
England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
We developed an
Xrcc4
M61R
separation of function mouse line to overcome the embryonic lethality of Xrcc4-deficient mice. XRCC4
M61R
protein does not interact with Xlf, thus obliterating XRCC4-Xlf filament formation while preserving the ability to stabilize DNA ligase IV. X4
M61R
mice, which are DNA repair deficient, phenocopy...
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An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development
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TN_cdi_doaj_primary_oai_doaj_org_article_9f2b7f8042e7416dbee800b5e8f5606b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9f2b7f8042e7416dbee800b5e8f5606b
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.69353
