Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 pro...
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism
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Author / Creator
Yan, Ying , Niu, Zhoumin , Sun, Chao , Li, Peng , Shen, Siyi , Liu, Shengnan , Wu, Yuting , Yun, Chuyu , Jiao, Tingying , Jia, Sheng , Li, Yuying , Fang, Zhong-Ze , Zhao, Lin , Wang, Jiqiu , Xie, Cen , Jiang, Changtao , Li, Yan , Feng, Xiaoyun , Hu, Cheng , Jiang, Jingjing and Ying, Hao
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely understood mechanisms. Here, we show that improved glucose metabolism in hypothyroid mice after T3 treatment is accompanied with increased glucagon-like peptide-1 (GLP-1) production and insulin secretion, while co-treatment with a GLP-1 receptor antagonist attenuates th...
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Full title
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism
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TN_cdi_doaj_primary_oai_doaj_org_article_9f34cb632cad4b8f9cd0da009ebed01b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9f34cb632cad4b8f9cd0da009ebed01b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34258-w
