Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons
Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Polycystic kidney disease (PKD) is a common genetic disorder arising from developmental and postnatal processes. Defects in primary cilia and their signaling (eg, mTOR) underlie the pathogenesis. However, how mTOR regulates tubular integrity remains unclear. The paucity of faithful models has limited our understanding of pathogenesis and, therefore...
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Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons
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TN_cdi_doaj_primary_oai_doaj_org_article_9f40ecc5fac241f3bd660204f929c27e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9f40ecc5fac241f3bd660204f929c27e
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-27766-2
