Transcriptional signature in microglia associated with Aβ plaque phagocytosis
Transcriptional signature in microglia associated with Aβ plaque phagocytosis
About this item
Full title
Author / Creator
Grubman, Alexandra , Choo, Xin Yi , Chew, Gabriel , Ouyang, John F. , Sun, Guizhi , Croft, Nathan P. , Rossello, Fernando J. , Simmons, Rebecca , Buckberry, Sam , Landin, Dulce Vargas , Pflueger, Jahnvi , Vandekolk, Teresa H. , Abay, Zehra , Zhou, Yichen , Liu, Xiaodong , Chen, Joseph , Larcombe, Michael , Haynes, John M. , McLean, Catriona , Williams, Sarah , Chai, Siew Yeen , Wilson, Trevor , Lister, Ryan , Pouton, Colin W. , Purcell, Anthony W. , Rackham, Owen J. L. , Petretto, Enrico and Polo, Jose M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4
+
) and non-containing (XO4
−
) microglia from an AD mouse model. Transcriptomics analysis identified different tr...
Alternative Titles
Full title
Transcriptional signature in microglia associated with Aβ plaque phagocytosis
Authors, Artists and Contributors
Author / Creator
Choo, Xin Yi
Chew, Gabriel
Ouyang, John F.
Sun, Guizhi
Croft, Nathan P.
Rossello, Fernando J.
Simmons, Rebecca
Buckberry, Sam
Landin, Dulce Vargas
Pflueger, Jahnvi
Vandekolk, Teresa H.
Abay, Zehra
Zhou, Yichen
Liu, Xiaodong
Chen, Joseph
Larcombe, Michael
Haynes, John M.
McLean, Catriona
Williams, Sarah
Chai, Siew Yeen
Wilson, Trevor
Lister, Ryan
Pouton, Colin W.
Purcell, Anthony W.
Rackham, Owen J. L.
Petretto, Enrico
Polo, Jose M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9f55b1d1d77043558956af5abec4909b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9f55b1d1d77043558956af5abec4909b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23111-1
