Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
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Author / Creator
Caron, Marie-Christine , Sharma, Ajit K. , O’Sullivan, Julia , Myler, Logan R. , Ferreira, Maria Tedim , Rodrigue, Amélie , Coulombe, Yan , Ethier, Chantal , Gagné, Jean-Philippe , Langelier, Marie-France , Pascal, John M. , Finkelstein, Ilya J. , Hendzel, Michael J. , Poirier, Guy G. and Masson, Jean-Yves
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
PARP-1 is rapidly recruited and activated by DNA double-strand breaks (DSBs). Upon activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose units that facilitates local chromatin relaxation and the recruitment of DNA repair factors. Here, we identify a function for PARP-1 in DNA DSB resection. Remarkably, inhibition of P...
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Full title
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9f5d756d157a42a383cdfc2eb5b3e5f7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9f5d756d157a42a383cdfc2eb5b3e5f7
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10741-9
