CTLA4-Ig treatment induces M1-M2 shift in cultured monocyte-derived macrophages from healthy subject...
CTLA4-Ig treatment induces M1-M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients
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England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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In rheumatoid arthritis (RA), macrophages play an important role in modulating the immunoinflammatory response through their polarisation into "classically" (M1) or "alternatively activated" (M2) phenotypes. In RA, CTLA4-Ig (abatacept) reduces the inflammatory activity of macrophages by interacting with the costimulatory molecule CD86. The study ai...
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CTLA4-Ig treatment induces M1-M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients
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TN_cdi_doaj_primary_oai_doaj_org_article_9f97748ebdd141d68a0c2fd8d848179a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9f97748ebdd141d68a0c2fd8d848179a
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ISSN
1478-6362,1478-6354
E-ISSN
1478-6362
DOI
10.1186/s13075-021-02691-9
