mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
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Author / Creator
Yan, Bo , Zhang, Zhongmin , Jin, Dadi , Cai, Chen , Jia, Chunhong , Liu, Wen , Wang, Ting , Li, Shengfa , Zhang, Haiyan , Huang, Bin , Lai, Pinglin , Wang, Hua , Liu, Anling , Zeng, Chun , Cai, Daozhang , Jiang, Yu and Bai, Xiaochun
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Precise coordination of cell growth, proliferation and differentiation is essential for the development of multicellular organisms. Here, we report that although the mechanistic target of rapamycin complex 1 (mTORC1) activity is required for chondrocyte growth and proliferation, its inactivation is essential for chondrocyte differentiation. Hyperac...
Alternative Titles
Full title
mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9fbf617daa9f4739bde05778746bcc00
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9fbf617daa9f4739bde05778746bcc00
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11151
