Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with...
Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder
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Author / Creator
Zastrozhin, Mikhail Sergeevich , Brodyansky, Vadim Markovich , Skryabin, Valentin Yurievich , Grishina, Elena Anatolievna , Ivashchenko, Dmitry Vladimirovich , Ryzhikova, Kristina Anatolievna , Savchenko, Ludmila Mikhaylovna , Kibitov, Alexander Olegovich , Bryun, Evgeny Alekseevich and Sychev, Dmitry Alekseevich
Publisher
New Zealand: Dove Medical Press Limited
Journal title
Language
English
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Publisher
New Zealand: Dove Medical Press Limited
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Scope and Contents
Contents
Antipsychotic action of haloperidol is due to blockade of D
receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D
receptor blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these receptors and associated structures (catechol-O-methyltransferas...
Alternative Titles
Full title
Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder
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TN_cdi_doaj_primary_oai_doaj_org_article_9ffd2de004ae43a88d0d80471b9998d6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9ffd2de004ae43a88d0d80471b9998d6
Other Identifiers
ISSN
1178-7066
E-ISSN
1178-7066
DOI
10.2147/PGPM.S140700
