Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A
Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A
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Author / Creator
Gao, Wei , Huang, Zhao , Duan, Jiufei , Nice, Edouard C. , Lin, Jie and Huang, Canhua
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
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Publication information
Publisher
United States: John Wiley & Sons, Inc
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Contents
Cancer cells reprogram their copper metabolism to adapt to adverse microenvironments, such as oxidative stress. The copper chelator elesclomol has been reported to have considerable anticancer efficacy, but the underlying mechanisms remain largely unknown. In this study, we found that elesclomol‐mediated copper overload inhibits colorectal cancer (...
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Full title
Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A
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TN_cdi_doaj_primary_oai_doaj_org_article_a004c29e4a7447ccb26c7e8b78992a28
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a004c29e4a7447ccb26c7e8b78992a28
Other Identifiers
ISSN
1574-7891
E-ISSN
1878-0261
DOI
10.1002/1878-0261.13079
