DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical associ...
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association
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Author / Creator
Lakis, Vanessa , Lawlor, Rita T. , Newell, Felicity , Patch, Ann-Marie , Mafficini, Andrea , Sadanandam, Anguraj , Koufariotis, Lambros T. , Johnston, Rebecca L. , Leonard, Conrad , Wood, Scott , Rusev, Borislav , Corbo, Vincenzo , Luchini, Claudio , Cingarlini, Sara , Landoni, Luca , Salvia, Roberto , Milella, Michele , Chang, David , Bailey, Peter , Jamieson, Nigel B. , Duthie, Fraser , Gingras, Marie-Claude , Muzny, Donna M. , Wheeler, David A. , Gibbs, Richard A. , Milione, Massimo , Pederzoli, Paolo , Samra, Jaswinder S. , Gill, Anthony J. , Johns, Amber L. , Pearson, John V. , Biankin, Andrew V. , Grimmond, Sean M. , Waddell, Nicola , Nones, Katia , Scarpa, Aldo , Garvan Institute of Medical Research , Bankstown Hospital , St Vincent’s Hospital , ARC-Net , Royal Adelaide Hospital , Royal North Shore Hospital , Envoi Pathology , QIMR Berghofer Medical Research Institute , Epworth Health Care , Prince of Wales Hospital , University of Melbourne: Centre for Cancer Research , Fiona Stanley Hospital , Liverpool Hospital , Austin Hospital , Johns Hopkins Medical Institutes , University of Glasgow , Flinders Medical Centre , Royal Prince Alfred Hospital Chris O’Brien Lifehouse , Westmead Hospital , APGI and Princess Alexandra Hospital
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups of PanNETs, termed T1, T2 and T3, with distinct patterns of methylation. The T1 subgroup was enriched for functional tumors and
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Alternative Titles
Full title
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association
Authors, Artists and Contributors
Author / Creator
Lawlor, Rita T.
Newell, Felicity
Patch, Ann-Marie
Mafficini, Andrea
Sadanandam, Anguraj
Koufariotis, Lambros T.
Johnston, Rebecca L.
Leonard, Conrad
Wood, Scott
Rusev, Borislav
Corbo, Vincenzo
Luchini, Claudio
Cingarlini, Sara
Landoni, Luca
Salvia, Roberto
Milella, Michele
Chang, David
Bailey, Peter
Jamieson, Nigel B.
Duthie, Fraser
Gingras, Marie-Claude
Muzny, Donna M.
Wheeler, David A.
Gibbs, Richard A.
Milione, Massimo
Pederzoli, Paolo
Samra, Jaswinder S.
Gill, Anthony J.
Johns, Amber L.
Pearson, John V.
Biankin, Andrew V.
Grimmond, Sean M.
Waddell, Nicola
Nones, Katia
Scarpa, Aldo
Garvan Institute of Medical Research
Bankstown Hospital
St Vincent’s Hospital
ARC-Net
Royal Adelaide Hospital
Royal North Shore Hospital
Envoi Pathology
QIMR Berghofer Medical Research Institute
Epworth Health Care
Prince of Wales Hospital
University of Melbourne: Centre for Cancer Research
Fiona Stanley Hospital
Liverpool Hospital
Austin Hospital
Johns Hopkins Medical Institutes
University of Glasgow
Flinders Medical Centre
Royal Prince Alfred Hospital Chris O’Brien Lifehouse
Westmead Hospital
APGI
Princess Alexandra Hospital
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a00f8e4047594060951453f3f2ee9216
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a00f8e4047594060951453f3f2ee9216
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-020-01469-0
