Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated. Countering models that presume antibodies are generated largely by stochastic processes, we demonstrate that polymorphisms within the immunoglobulin...
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Full title
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
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TN_cdi_doaj_primary_oai_doaj_org_article_a0183aabadc24385b06da65e954df467
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a0183aabadc24385b06da65e954df467
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40070-x
