A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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In sepsis, limited food intake and increased energy expenditure induce a starvation response, which is compromised by a quick decline in the expression of hepatic PPARα, a transcription factor essential in intracellular catabolism of free fatty acids. The mechanism upstream of this PPARα downregulation is unknown. We found that sepsis causes a prog...
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A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
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TN_cdi_doaj_primary_oai_doaj_org_article_a06f4ebf50eb4404b264053ba4838ecb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a06f4ebf50eb4404b264053ba4838ecb
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ISSN
1757-4684,1757-4676
E-ISSN
1757-4684
DOI
10.1038/s44321-024-00130-1
