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A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a06f4ebf50eb4404b264053ba4838ecb

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

About this item

Full title

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Publisher

London: Nature Publishing Group UK

Journal title

EMBO molecular medicine, 2024-09, Vol.16 (10), p.2485-2515

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

In sepsis, limited food intake and increased energy expenditure induce a starvation response, which is compromised by a quick decline in the expression of hepatic PPARα, a transcription factor essential in intracellular catabolism of free fatty acids. The mechanism upstream of this PPARα downregulation is unknown. We found that sepsis causes a prog...

Alternative Titles

Full title

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_a06f4ebf50eb4404b264053ba4838ecb

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a06f4ebf50eb4404b264053ba4838ecb

Other Identifiers

ISSN

1757-4684,1757-4676

E-ISSN

1757-4684

DOI

10.1038/s44321-024-00130-1

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