SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-de...
SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production
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Author / Creator
Chen, Liyun , Shi, Victoria , Wang, Songyan , Sun, Lulu , Freeman, Rebecca , Yang, Jasmine , Inkman, Matthew J , Ghosh, Subhajit , Ruiz, Fiona , Jayachandran, Kay , Huang, Yi , Luo, Jingqin , Zhang, Jin , Cosper, Pippa , Luke, Clifford J , Spina, Catherine S , Grigsby, Perry W , Schwarz, Julie K and Markovina, Stephanie
Publisher
American Society for Clinical Investigation
Journal title
Language
English
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Publisher
American Society for Clinical Investigation
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Contents
Patients with cancer who have high serum levels of squamous cell carcinoma antigen 1 (SCCA1, now referred to as SERPINB3) commonly experience treatment resistance and have a poor prognosis. Despite being a clinical biomarker, the modulation of SERPINB3 in tumor immunity is poorly understood. We found positive correlations of SERPINB3 with CXCL1, CX...
Alternative Titles
Full title
SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a09211f5a61947efb47a9d24712b29ab
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a09211f5a61947efb47a9d24712b29ab
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI163841
