Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac tro...
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients
About this item
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Author / Creator
Yuda, Junichiro , Will, Christine , Phillips, Darren C. , Abraham, Linu , Alvey, Cory , Avigdor, Abraham , Buck, Wayne , Besenhofer, Lauren , Boghaert, Erwin , Cheng, Dong , Cojocari, Dan , Doyle, Kelly , Hansen, T. Matthew , Huang, Kevin , Johnson, Eric F. , Judd, Andrew S. , Judge, Russell A. , Kalvass, John C. , Kunzer, Aaron , Lam, Lloyd T. , Li, Rachel , Martin, Ruth L. , Mastracchio, Anthony , Mitten, Mike , Petrich, Adam , Wang, Jin , Ward, James E. , Zhang, Haichao , Wang, Xilu , Wolff, Johannes E. , Bell-McGuinn, Katherine M. and Souers, Andrew J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
MCL-1 is a prosurvival B-cell lymphoma 2 family protein that plays a critical role in tumor maintenance and survival and can act as a resistance factor to multiple anticancer therapies. Herein, we describe the generation and characterization of the highly potent and selective MCL-1 inhibitor ABBV-467 and present findings from a first-...
Alternative Titles
Full title
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients
Authors, Artists and Contributors
Author / Creator
Will, Christine
Phillips, Darren C.
Abraham, Linu
Alvey, Cory
Avigdor, Abraham
Buck, Wayne
Besenhofer, Lauren
Boghaert, Erwin
Cheng, Dong
Cojocari, Dan
Doyle, Kelly
Hansen, T. Matthew
Huang, Kevin
Johnson, Eric F.
Judd, Andrew S.
Judge, Russell A.
Kalvass, John C.
Kunzer, Aaron
Lam, Lloyd T.
Li, Rachel
Martin, Ruth L.
Mastracchio, Anthony
Mitten, Mike
Petrich, Adam
Wang, Jin
Ward, James E.
Zhang, Haichao
Wang, Xilu
Wolff, Johannes E.
Bell-McGuinn, Katherine M.
Souers, Andrew J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a09a2953c50e4da8ad9915dfa149ffac
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a09a2953c50e4da8ad9915dfa149ffac
Other Identifiers
ISSN
2730-664X
E-ISSN
2730-664X
DOI
10.1038/s43856-023-00380-z
