miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures, is invariably associated with poor patient survival. We demonstrate that stroma exerts a key function in mesenchymal HGSOC. We highlight stromal heterogeneity in HGSOC by identifying fou...
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Full title
miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
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TN_cdi_doaj_primary_oai_doaj_org_article_a09f89d7e4cd4d8ebd1d78403faf2e10
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a09f89d7e4cd4d8ebd1d78403faf2e10
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03348-z
