A human multi-lineage hepatic organoid model for liver fibrosis
A human multi-lineage hepatic organoid model for liver fibrosis
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Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
To investigate the pathogenesis of a congenital form of hepatic fibrosis, human hepatic organoids were engineered to express the most common causative mutation for Autosomal Recessive Polycystic Kidney Disease (ARPKD). Here we show that these hepatic organoids develop the key features of ARPKD liver pathology (abnormal bile ducts and fibrosis) in o...
Alternative Titles
Full title
A human multi-lineage hepatic organoid model for liver fibrosis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a0a7c814994743da9ab4dcaf12e47001
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a0a7c814994743da9ab4dcaf12e47001
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26410-9
