Parkin coregulates glutathione metabolism in adult mammalian brain
Parkin coregulates glutathione metabolism in adult mammalian brain
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Author / Creator
El Kodsi, Daniel N , Tokarew, Jacqueline M , Sengupta, Rajib , Lengacher, Nathalie A , Chatterji, Ajanta , Nguyen, Angela P , Boston, Heather , Jiang, Qiubo , Palmberg, Carina , Pileggi, Chantal , Holterman, Chet E , Shutinoski, Bojan , Li, Juan , Fehr, Travis K , LaVoie, Matthew J , Ratan, Rajiv R , Shaw, Gary S , Takanashi, Masashi , Hattori, Nobutaka , Kennedy, Christopher R , Harper, Mary-Ellen , Holmgren, Arne , Tomlinson, Julianna J and Schlossmacher, Michael G
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn with Sod2 haploinsufficiency in mice. Although adult prkn
//Sod2
animals did not develop dopamine cell...
Alternative Titles
Full title
Parkin coregulates glutathione metabolism in adult mammalian brain
Authors, Artists and Contributors
Author / Creator
Tokarew, Jacqueline M
Sengupta, Rajib
Lengacher, Nathalie A
Chatterji, Ajanta
Nguyen, Angela P
Boston, Heather
Jiang, Qiubo
Palmberg, Carina
Pileggi, Chantal
Holterman, Chet E
Shutinoski, Bojan
Li, Juan
Fehr, Travis K
LaVoie, Matthew J
Ratan, Rajiv R
Shaw, Gary S
Takanashi, Masashi
Hattori, Nobutaka
Kennedy, Christopher R
Harper, Mary-Ellen
Holmgren, Arne
Tomlinson, Julianna J
Schlossmacher, Michael G
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a0cf0ed0ee2143f0a980d7d5a5c6d50a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a0cf0ed0ee2143f0a980d7d5a5c6d50a
Other Identifiers
ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-022-01488-4
