Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
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Cambridge: eLife Sciences Publications Ltd
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Language
English
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Cambridge: eLife Sciences Publications Ltd
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To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with Fas in vivo. We found that FasL interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as death receptor (DR)5. Autoantibody-induced arthritis (AIA) was attenuated in FasL (
Fasl
gl...
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Full title
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
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TN_cdi_doaj_primary_oai_doaj_org_article_a0f6432c11da4cc0b1a3161c6a7aed87
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a0f6432c11da4cc0b1a3161c6a7aed87
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.48840
