Structural basis for the activation of the lipid scramblase TMEM16F
Structural basis for the activation of the lipid scramblase TMEM16F
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
TMEM16F, a member of the conserved TMEM16 family, plays a central role in the initiation of blood coagulation and the fusion of trophoblasts. The protein mediates passive ion and lipid transport in response to an increase in intracellular Ca
2+
. However, the mechanism of how the protein facilitates both processes has remained elusive. Here w...
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Full title
Structural basis for the activation of the lipid scramblase TMEM16F
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TN_cdi_doaj_primary_oai_doaj_org_article_a10f4da2d5df4295bf36f7cbb6a7793d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a10f4da2d5df4295bf36f7cbb6a7793d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34497-x
