iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
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Author / Creator
Chen, Delin , Chu, Bo , Yang, Xin , Liu, Zhaoqi , Jin, Ying , Kon, Ning , Rabadan, Raul , Jiang, Xuejun , Stockwell, Brent R. and Gu, Wei
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Here, we identify iPLA2β as a critical regulator for p53-driven ferroptosis upon reactive oxygen species (ROS)-induced stress. The calcium-independent phospholipase iPLA2β is known to cleave acyl tails from the glycerol backbone of lipids and release oxidized fatty acids from phospholipids. We found that iPLA2β-mediated detoxification of peroxidize...
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Full title
iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
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TN_cdi_doaj_primary_oai_doaj_org_article_a120a8ca7a5849038e10bdd49256abdc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a120a8ca7a5849038e10bdd49256abdc
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23902-6
