Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosph...
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Regulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production of IL-10. Here we demonstrate that the induction of a regulatory program in human B cells is dependent on a metabolic priming event driven by cholesterol metabolism. Synthesis of the metabolic interme...
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Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
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TN_cdi_doaj_primary_oai_doaj_org_article_a13c8e4f4fa14c78ae7364c2bdf52f9c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a13c8e4f4fa14c78ae7364c2bdf52f9c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17179-4
