Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-defic...
Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex, is the causative gene of rhabdoid tumors and epithelioid sarcomas. Here, we identify a paralog pair of CBP and p300 as a synthetic lethal target in SMARCB1-deficient cancers by using a dual siRNA screening method based on the “simultaneous inhibition of a paralog pair” concept. Treatme...
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Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers
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TN_cdi_doaj_primary_oai_doaj_org_article_a1683ef28c364d7fb8a397fee77e023c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a1683ef28c364d7fb8a397fee77e023c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-49063-w
