Hierarchical annotation of eQTLs by H-eQTL enables identification of genes with cell type-divergent...
Hierarchical annotation of eQTLs by H-eQTL enables identification of genes with cell type-divergent regulation
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Publisher
England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Contents
While context-type-specific regulation of genes is largely determined by cis-regulatory regions, attempts to identify cell type-specific eQTLs are complicated by the nested nature of cell types. We present hierarchical eQTL (H-eQTL), a network-based model for hierarchical annotation of bulk-derived eQTLs to levels of a cell type tree using single-c...
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Hierarchical annotation of eQTLs by H-eQTL enables identification of genes with cell type-divergent regulation
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TN_cdi_doaj_primary_oai_doaj_org_article_a1efd200c7d741d9b98a0ece02df5856
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a1efd200c7d741d9b98a0ece02df5856
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ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-024-03440-2
