Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
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Author / Creator
Gao, Lei , Hu, Yong , Tian, Yahui , Fan, Zhenzhen , Wang, Kun , Li, Hongdan , Zhou, Qian , Zeng, Guandi , Hu, Xin , Yu, Lei , Zhou, Shiyu , Tong, Xinyuan , Huang, Hsinyi , Chen, Haiquan , Liu, Qingsong , Liu, Wanting , Zhang, Gong , Zeng, Musheng , Zhou, Guangbiao , He, Qingyu , Ji, Hongbin and Chen, Liang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Lung cancer is the leading cause of cancer-related deaths worldwide. Tumor suppressor genes remain to be systemically identified for lung cancer. Through the genome-wide screening of tumor-suppressive transcription factors, we demonstrate here that GATA4 functions as an essential tumor suppressor in lung cancer in vitro and in vivo. Ectopic GATA4 e...
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Full title
Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
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TN_cdi_doaj_primary_oai_doaj_org_article_a22e2b802e16470085f09c63c8826bf0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a22e2b802e16470085f09c63c8826bf0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09295-7
