Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using a Quantum pBac-based CAR-T...
Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using a Quantum pBac-based CAR-T engineering system
About this item
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Author / Creator
Chang, Peter S , Chen, Yi-Chun , Hua, Wei-Kai , Hsu, Jeff C , Tsai, Jui-Cheng , Huang, Yi-Wun , Kao, Yi-Hsin , Wu, Pei-Hua , Wang, Po-Nan , Chang, Yi-Fang , Chang, Ming-Chih , Chang, Yu-Cheng , Jian, Shiou-Ling , Lai, Jiann-Shiun , Lai, Ming-Tain , Yang, Wei-Cheng , Shen, Chia-Ning , Wen, Kuo-Lan Karen and Wu, Sareina Chiung-Yuan
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
CD19-targeted chimeric antigen receptor (CAR) T cell therapies have driven a paradigm shift in the treatment of relapsed/refractory B-cell malignancies. However, >50% of CD19-CAR-T-treated patients experience progressive disease mainly due to antigen escape and low persistence. Clinical prognosis is heavily influenced by CAR-T cell function and sys...
Alternative Titles
Full title
Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using a Quantum pBac-based CAR-T engineering system
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a24dce73854148dc9828f7489ea2bfaa
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a24dce73854148dc9828f7489ea2bfaa
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0309245
