The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following prote...
The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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We examined the feedback between the major protein degradation pathway, the ubiquitin-proteasome system (UPS), and protein synthesis in rat and mouse neurons. When protein degradation was inhibited, we observed a coordinate dramatic reduction in nascent protein synthesis in neuronal cell bodies and dendrites. The mechanism for translation inhibitio...
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The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
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TN_cdi_doaj_primary_oai_doaj_org_article_a2a91b9d6fb5494ea948d96533c2e08d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a2a91b9d6fb5494ea948d96533c2e08d
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.52714
