Comparisons of In Vivo and In Vitro Opioid Effects of Newly Synthesized 14-Methoxycodeine-6- O -sulf...
Comparisons of In Vivo and In Vitro Opioid Effects of Newly Synthesized 14-Methoxycodeine-6- O -sulfate and Codeine-6- O -sulfate
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Switzerland: MDPI AG
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English
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Publisher
Switzerland: MDPI AG
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The present work represents the in vitro (potency, affinity, efficacy) and in vivo (antinociception, constipation) opioid pharmacology of the novel compound 14-methoxycodeine-6-
-sulfate (14-OMeC6SU), compared to the reference compounds codeine-6-
-sulfate (C6SU), codeine and morphine. Based on in vitro tests (mouse and rat vas deferens, rece...
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Comparisons of In Vivo and In Vitro Opioid Effects of Newly Synthesized 14-Methoxycodeine-6- O -sulfate and Codeine-6- O -sulfate
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TN_cdi_doaj_primary_oai_doaj_org_article_a3369a5ac33645918898849b78f5c94e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a3369a5ac33645918898849b78f5c94e
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules25061370
