Role of Bruton’s tyrosine kinase in B cells and malignancies
Role of Bruton’s tyrosine kinase in B cells and malignancies
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was initially shown to be defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) and is essential both for B cell development...
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Full title
Role of Bruton’s tyrosine kinase in B cells and malignancies
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TN_cdi_doaj_primary_oai_doaj_org_article_a338eedb1cad439b94788fda894fdea3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a338eedb1cad439b94788fda894fdea3
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ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-018-0779-z
