Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformat...
Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain movements that include the substrate-binding transport domain and the scaffold domain. Here, we present cryo-EM structures of...
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Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation
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TN_cdi_doaj_primary_oai_doaj_org_article_a33c8724acd14c1bb4ac82ee1b35322f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a33c8724acd14c1bb4ac82ee1b35322f
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.48120
