Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensiti...
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer
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Author / Creator
Shi, Wengui , Zhang, Gengyuan , Ma, Zhijian , Li, Lianshun , Liu, Miaomiao , Qin, Long , Yu, Zeyuan , Zhao, Lei , Liu, Yang , Zhang, Xue , Qin, Junjie , Ye, Huili , Jiang, Xiangyan , Zhou, Huinian , Sun, Hui and Jiao, Zuoyi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Trastuzumab is the backbone of HER2-directed gastric cancer therapy, but poor patient response due to insufficient cell sensitivity and drug resistance remains a clinical challenge. Here, we report that HER2 is involved in cell mitotic promotion for tumorigenesis by hyperactivating a crucial HER2-SHCBP1-PLK1 axis that drives trastuzumab sensitivity...
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Full title
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_a36742197f8f4e5f8d941649431f83ec
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a36742197f8f4e5f8d941649431f83ec
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23053-8
