Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug...
Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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To better understand drug resistance mechanisms to CDK4/6 inhibitors and inform precision medicine, we analyze real-world multi-omics data from 400 HR+/HER2- metastatic breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapies, including 200 pre-treatment and 227 post-progression samples. The prevalences of
ESR1
and
RB...
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Full title
Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors
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TN_cdi_doaj_primary_oai_doaj_org_article_a386a891e600428c99ba0e1e1867b722
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a386a891e600428c99ba0e1e1867b722
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-55914-x
