The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammat...
The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammatory syndrome in children
About this item
Full title
Author / Creator
Benamar, Mehdi , Chen, Qian , Chou, Janet , Julé, Amélie M. , Boudra, Rafik , Contini, Paola , Crestani, Elena , Lai, Peggy S. , Wang, Muyun , Fong, Jason , Rockwitz, Shira , Lee, Pui , Chan, Tsz Man Fion , Altun, Ekin Zeynep , Kepenekli, Eda , Karakoc-Aydiner, Elif , Ozen, Ahmet , Boran, Perran , Aygun, Fatih , Onal, Pinar , Sakalli, Ayse Ayzit Kilinc , Cokugras, Haluk , Gelmez, Metin Yusuf , Oktelik, Fatma Betul , Cetin, Esin Aktas , Zhong, Yuelin , Taylor, Maria Lucia , Irby, Katherine , Halasa, Natasha B. , Mack, Elizabeth H. , Signa, Sara , Prigione, Ignazia , Gattorno, Marco , Cotugno, Nicola , Amodio, Donato , Geha, Raif S. , Son, Mary Beth , Newburger, Jane , Agrawal, Pankaj B. , Volpi, Stefano , Palma, Paolo , Kiykim, Ayca , Randolph, Adrienne G. , Deniz, Gunnur , Baris, Safa , De Palma, Raffaele , Schmitz-Abe, Klaus , Charbonnier, Louis-Marie , Henderson, Lauren A. , Chatila, Talal A. and Overcoming COVID-19 Investigators
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were previously correlated with Notch4 expression on Tregs, here, we show that Tregs in MIS-C were destabilized through a Notch1-dependent mec...
Alternative Titles
Full title
The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammatory syndrome in children
Authors, Artists and Contributors
Author / Creator
Chen, Qian
Chou, Janet
Julé, Amélie M.
Boudra, Rafik
Contini, Paola
Crestani, Elena
Lai, Peggy S.
Wang, Muyun
Fong, Jason
Rockwitz, Shira
Lee, Pui
Chan, Tsz Man Fion
Altun, Ekin Zeynep
Kepenekli, Eda
Karakoc-Aydiner, Elif
Ozen, Ahmet
Boran, Perran
Aygun, Fatih
Onal, Pinar
Sakalli, Ayse Ayzit Kilinc
Cokugras, Haluk
Gelmez, Metin Yusuf
Oktelik, Fatma Betul
Cetin, Esin Aktas
Zhong, Yuelin
Taylor, Maria Lucia
Irby, Katherine
Halasa, Natasha B.
Mack, Elizabeth H.
Signa, Sara
Prigione, Ignazia
Gattorno, Marco
Cotugno, Nicola
Amodio, Donato
Geha, Raif S.
Son, Mary Beth
Newburger, Jane
Agrawal, Pankaj B.
Volpi, Stefano
Palma, Paolo
Kiykim, Ayca
Randolph, Adrienne G.
Deniz, Gunnur
Baris, Safa
De Palma, Raffaele
Schmitz-Abe, Klaus
Charbonnier, Louis-Marie
Henderson, Lauren A.
Chatila, Talal A.
Overcoming COVID-19 Investigators
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a39c807bcee64be782682857c935eead
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a39c807bcee64be782682857c935eead
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI163235
