Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
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Author / Creator
Pavic, Karolina , Gupta, Nikhil , Omella, Judit Domènech , Derua, Rita , Aakula, Anna , Huhtaniemi, Riikka , Määttä, Juha A. , Höfflin, Nico , Okkeri, Juha , Wang, Zhizhi , Kauko, Otto , Varjus, Roosa , Honkanen, Henrik , Abankwa, Daniel , Köhn, Maja , Hytönen, Vesa P. , Xu, Wenqing , Nilsson, Jakob , Page, Rebecca , Janssens, Veerle , Leitner, Alexander and Westermarck, Jukka
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly understood. Here, we report molecular level details and structural mechanisms of PP2A-B56α inhibition by an oncoprotein CIP2A. Upon direct binding to PP2A-B56α trimer, CIP2A displaces the...
Alternative Titles
Full title
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
Authors, Artists and Contributors
Author / Creator
Gupta, Nikhil
Omella, Judit Domènech
Derua, Rita
Aakula, Anna
Huhtaniemi, Riikka
Määttä, Juha A.
Höfflin, Nico
Okkeri, Juha
Wang, Zhizhi
Kauko, Otto
Varjus, Roosa
Honkanen, Henrik
Abankwa, Daniel
Köhn, Maja
Hytönen, Vesa P.
Xu, Wenqing
Nilsson, Jakob
Page, Rebecca
Janssens, Veerle
Leitner, Alexander
Westermarck, Jukka
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a40d0289287e4365ac202e20daf82ec2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a40d0289287e4365ac202e20daf82ec2
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36693-9
